The lack of antifungal drugs with novel modes of action reaching the clinic is a serious concern.Recently a novel antifungal protein referred to as Blad-containing oligomer (BCO) has received regulatory approval as an agricultural antifungal agent.Interestingly its spectrum of antifungal activity includes human pathogens such as Candida albicans, h
Combining immunotherapy with oncogene-targeted therapy: a new road for melanoma treatment
Cutaneous melanoma arises from the malignant transformation of skin melanocytes; its incidence and mortality have been increasing steadily over the last fifty-years, now representing 3% of total tumors.Once melanoma metastasizes, prognosis is somber and therapeutic options are limited.However, the discovery of prevalent BRAF mutations in at least 5
Morbidity and mortality associated with Plasmodium vivax and Plasmodium falciparum infection in a tertiary care kidney hospital
Malaria is a disease of tropical regions and both types of plasmodia, i.e.Plasmodium falciparum and Plasmodium vivax, cause significant morbidity and mortality.P.vivax was thought to be benign and cause less morbidity and mortality.Many reports showed the devastating effect of vivax malaria too.We compared the clinical symptoms, laboratory markers,
A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities.
Timely regulation of carbon metabolic pathways is essential for cellular processes and to prevent futile cycling of intracellular metabolites.In Halobacterium salinarum, a hypersaline adapted archaeon, a sugar-sensing TrmB family protein controls gluconeogenesis Lipstick and other biosynthetic pathways.Notably, Hbt.salinarum does not utilize carboh